New research by BioCC: Probiotic Lactobacillus plantarum Inducia Contributes to the Prevention of Clostridioides Difficile Spore Germination and Induces Modulation of Innate Immune Markers (Results of Clinical Trials). | BioCC OÜ

New research by BioCC: Probiotic Lactobacillus plantarum Inducia® Contributes to the Prevention of Clostridioides Difficile Spore Germination and Induces Modulation of Innate Immune Markers

The probiotic L. plantarum strain INDUCIA® in synbiotic combination with xylitol has proved the possibility to prevent antimicrobial treatment-associated C. difficile infection and its recurrences.

A variety of functional properties of the probiotic L. plantarum Inducia contribute to antagonistic effect against C. difficile

The strain enhances natural cellular immunity and barrier function of gut mucosa via secretion of plantaricins, induction of cytokine IL-6, production of putrescine and increases the amount of lymphatic tissue in intestine. Strong antioxidative activity gives L. plantarum INDUCIA an extra protection, helping to counteract the oxidative stress imposed by bile acids or C. difficile associated inflammation-induced oxidative stress.

The combination of  L. plantarum Inducia with  prebiotic xylitol suppresses the germination of spores and outgrowth into vegetative toxin producing cells of C. difficile and could reduce the colonization of gut with the pathogen

Polyamines of human strain Lactobacillus plantarum Inducia induce modulation of innate immune markers

The strains’ genes for polyamines, and amino acid metabolites were tested. Edam-type cheese comprised with putrescine producing strain Inducia, and control cheese were administered to n = 20 NIH-line mice and tested in 12 healthy Estonian volunteers (ISRCTN38739209) consuming 50 g Inducia cheese (3 × 109 CFU/daily) and control cheese in blinded placebo-controlled 3-week cross-over trial In experimental mice the amount of ileal and colonic lymphatic tissue, the count and diversity of lactobacilli increased. In volunteers’ urine acetylated putrescine (p = 0.021); monocytes (p = 0.032), and cytokine IL-6 (p = 0.020) content in blood increased moderately.

  • The increase of lactobacilli and lymphocytes in the ileal and colonic mucosa of NIH line mice was detected
  • In volunteers the increase of ac- putrescine, IL-6 and monocytes amount took place after Inducia cheese consumption.
  • activation of some immunological parameters was detected: increase of N-acetylated putrescine in the urine of volunteers was followed by a moderate increase of the number of blood monocytes and IL-6.

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